![]() ![]() There was a poor but non-significant reduction in systolic BP (−0.033 ± 4.71 mmHg, p = 0.531) in the intervention group. The mean 25(OH)D level increased to 28.9 ± 11.7 ng/mL (p < 0.001) in the intervention group. During the trial 6-minute walk test (6MWT), 25-hydroxyvitamin D (25D) level, BP, sodium and potassium intakes were assessed. Thirty-nine systolic HF patients with low ejection fraction (EF) < 50% and class III of New York Heart Association functional classification were randomly divided into 2 groups including intervention and placebo to enroll in an 8 weeks double-blind clinical trial. This study aims to investigate the effect of vitamin D supplements on blood pressure (BP) and physical activity of HF patients. ![]() Vitamin D deficiency has been observed widespread amongst heart failure (HF) patients, which could have harmful effects on their health condition. The receptor of vitamin D is expressed in almost all body cells, including vascular endothelial cells and cardiomyocytes.
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